女性使用永久性染发剂并不会增加大多数癌症风险和相关死亡率—小柯机器人—科学网

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发布时间:2020-09-10

女性使用永久性染发剂并不会增加大多数癌症风险和相关死亡率

美国布列根和妇女医院和哈佛医学院Eva S Schernhammer团队研究了美国女性使用永久性染发剂与癌症风险和死亡率的关系。2020年9月2日,该研究发表在《英国医学杂志》上。

为了探究个人使用永久性染发剂与癌症风险和死亡率的相关性,研究组展开了一项前瞻性队列研究,招募了117200名女护士,基线时均没有癌症,所有参与者都报告个人使用永久性染发剂的信息,并随访36年。

结果发现使用永久性染发剂的参与者与未使用者相比,患实体癌(共20805事例,非黑色素瘤皮肤癌除外)和肝脏系统癌症的风险均未显著增加(1807事例)。此外,用于染发剂的参与者特定癌症的风险未明显减少,还包括皮肤鳞状细胞癌、膀胱癌、黑色素瘤、雌激素受体阳性乳腺癌、孕激素受体阳性乳腺癌、激素受体阳性乳腺癌、脑癌、结肠直肠癌、肾癌、肺癌、以及大多数主要亚类和的组织亚型的造血系统癌症,癌症相关丧生风险亦未明显减少(4860事例)。

但使用染色剂的参与者与未使用者比起,基底细胞癌风险略有增加(共22560例,风险比为1.05)。染发剂积累剂量与雌激素受体阴性乳腺癌、孕激素受体阴性乳腺癌、激素受体阴性乳腺癌和卵巢癌的风险呈正相关。天生深发色的女性中霍奇金淋巴瘤的风险增加,而天生深发色的女性中基底细胞癌风险较高。

总之,个人使用永久性染发剂与大多数癌症风险和与癌症相关的死亡率并不相关,但基底细胞癌、乳腺癌(雌激素受体阴性、孕激素受体阴性、激素受体阴性)和卵巢癌的风险有所增加。

所附:英文原文

Title: Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study

Author: Yin Zhang, Brenda M Birmann, Jiali Han, Edward L Giovannucci, Frank E Speizer, Meir J Stampfer, Bernard A Rosner, Eva S Schernhammer

Issue&Volume: 2020/09/02

Abstract: Objective To evaluate the associations between personal use of permanent hair dyes and cancer risk and mortality.

Design Prospective cohort study.

Setting and participants 117200 women enrolled in the Nurses’ Health Study, an ongoing prospective cohort study of female nurses in the United States. The women were free of cancer at baseline, reported information on personal use of permanent hair dyes, and were followed for 36 years.

Exposure Status, duration, frequency, and integral use (cumulative dose calculated from duration and frequency) of permanent hair dyes. Age at first use and time since first use of permanent hair dyes.

Main outcome measures Associations of personal use of permanent hair dyes with risk of overall cancer and specific cancers, and cancer related death. Age and multivariable adjusted hazard ratios and 95% confidence intervals were estimated by using Cox proportional hazard models.

Results Ever users of permanent hair dyes had no significant increases in risk of solid cancers (n=20805, excluding non-melanoma skin cancers; hazard ratio 0.98, 95% confidence interval 0.96 to 1.01) or hematopoietic cancers overall (n=1807; 1.00, 0.91 to 1.10) compared with non-users. Additionally, ever users did not have an increased risk of most specific cancers (cutaneous squamous cell carcinoma, bladder cancer, melanoma, estrogen receptor positive breast cancer, progesterone receptor positive breast cancer, hormone receptor positive breast cancer, brain cancer, colorectal cancer, kidney cancer, lung cancer, and most of the major subclasses and histological subtypes of hematopoietic cancer) or cancer related death (n=4860; 0.96, 0.91 to 1.02). Basal cell carcinoma risk was slightly increased for ever users (n=22560; 1.05, 1.02 to 1.08). Cumulative dose was positively associated with risk of estrogen receptor negative breast cancer, progesterone receptor negative breast cancer, hormone receptor negative breast cancer, and ovarian cancer. An increased risk of Hodgkin lymphoma was observed only for women with naturally dark hair (based on 70 women, 24 with dark hair), and a higher risk of basal cell carcinoma was observed for women with naturally light hair.

Conclusion No positive association was found between personal use of permanent hair dye and risk of most cancers and cancer related mortality. The increased risk of basal cell carcinoma, breast cancer (estrogen receptor negative, progesterone receptor negative, hormone receptor negative) and ovarian cancer, and the mixed findings in analyses stratified by natural hair color warrant further investigation.

DOI: 10.1136/bmj.m2942

Source: https://www.bmj.com/content/370/bmj.m2942

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